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<!DOCTYPE html>
<html>
<head>
<script class="jsbin" src="http://ajax.googleapis.com/ajax/libs/jquery/1.4.2/jquery.min.js"></script>
  
  <script type="text/javascript">
  
    $(document).ready(
      function() {
        $('option[value=AB]').attr('disabled', 'disabled');
      }
      );
    
  </script>
<meta charset=utf-8 />
<title>JS Bin</title>
<!--[if IE]>
  <script src="http://html5shiv.googlecode.com/svn/trunk/html5.js"></script>
<![endif]-->
<style>
  article, aside, figure, footer, header, hgroup, 
  menu, nav, section { display: block; }
</style>
</head>
<body>
  
<form action="" method="post">
  <fieldset>
    <select id ="myselect">
        <option value="AA">AA</option>
        <option value="AB">AB</option>
        <option value="AC">AC</option>
        <option value="AD">AD</option>
     </select>
  </fieldset>
</form>
</body>
</html>
Output

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